నైరూప్య

Synthesis of 1-substituted-2-thio-(1H)-4-(3-phenylthiocarbamido-1-yl)- 6-(1-substitutedguanidino-3-yl)-1,2-dihydro-s-triazine

M.E.Shelke, P.R.Malasane

Novel series of 1-substituted-2-thio-(1H)-4-(3-phenylthiocarbamido-1-yl)- 6-(1-substituted- guanidino-3-yl)-1,2-dihydro-s-triazine (4a(i) to 4f(ii)) has been obtained by the isomerisation of 2-(1- substitutedguanidino-3-yl)-4- (3-phenylthiocarbamido-1-yl)-6- substitutedimino-1,3,5-thiadiazine (3a(i) to 3f(ii)) in presence of ethanolic sodium bicarbonate solution, which have been obtained by basification of their hydrochlorides (2a(i) to 2f(ii)) which are synthesized by the interaction of 1-Formamidino- (N- substitutedthioamido)- 5-phenyl-2-thio-4-iminobiuret (1a-f) and N-aryl/alkylisocyanodichlorides. The latter were prepared initially by the condensation of N-aryl/alkylisothiocyanate withN-phenylformamidinoformamidinothiocarbamide. The structure of all these compounds was established on the basis of elemental analysis, IR and PMR spectral data.