నైరూప్య

A validated chiral LC method for enantiomeric separation of common intermediate of ritonavir and lopinavir using cellulose based chiral stationary phase

A.Nageswari, P.Surya Prakash Rao, B.Gowri Sankar Rao, B.Satyanarayana, CH. Sridhar, V.Ranga Reddy, Mukkanti


A rapid isocratic chiral LCmethod has been developed for the separation of (2R,3R,5R)-2-Amino-3-hydroxy-5-(tert-butyl oxy carbonyl) amino-1,6-diphenyl hemi succinic acid (R-BOCamine) from(2S,3S,5S)-2-Amino-3-hydroxy- 5-(tert-butyl oxy carbonyl) amino-1,6-diphenyl hemi succinic acid (S-BOC amine). Good resolution with RS > 3 was obtained using cellulose based chiral stationary phase, chiralcelOD-H column (250 x 4.6mm, 5µm particle size) and n-hexane, ethanol, trifluoroacetic acid and triethyl amine (950:50:1:1,v/v) as themobile phase at ambient temperature. Flowrate was kept at 1.0 mLmin-1 and elution wasmonitored by UV detection at 210 nm. This method allowed for the detection and quantification of R-BOC amine of levels at 0.15 and 0.5 µg mL-1 respectively. Themethod was validated by following ICH guidelines.


ఇండెక్స్ చేయబడింది

  • CASS
  • గూగుల్ స్కాలర్
  • J గేట్ తెరవండి
  • చైనా నేషనల్ నాలెడ్జ్ ఇన్‌ఫ్రాస్ట్రక్చర్ (CNKI)
  • CiteFactor
  • కాస్మోస్ IF
  • ఎలక్ట్రానిక్ జర్నల్స్ లైబ్రరీ
  • రీసెర్చ్ జర్నల్ ఇండెక్సింగ్ డైరెక్టరీ (DRJI)
  • రహస్య శోధన ఇంజిన్ ల్యాబ్‌లు
  • ICMJE

మరిన్ని చూడండి

జర్నల్ హెచ్-ఇండెక్స్

Flyer